Every individual person who wants to sign electronic orders for controlled substances must enroll with DEA to acquire his or her own personal CSOS Certificate. The following enrollment process will step you through the requirements for enrolling with DEA. At the end of this enrollment process you will be asked to complete an application package that is to be mailed to DEA.

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The simplest, most cost-effective solution for eliminating DEA paper Form 222 and ensuring DEA compliance. Express222™ is a 100% web-based Controlled Substance Ordering System (CSOS) that delivers all the benefits of electronic controlled substance ordering and fulfillment with some surprising differences.